Graph-based optimization of epitope coverage for vaccine antigen design
نویسندگان
چکیده
منابع مشابه
Graph‐based optimization of epitope coverage for vaccine antigen design
Epigraph is a recently developed algorithm that enables the computationally efficient design of single or multi-antigen vaccines to maximize the potential epitope coverage for a diverse pathogen population. Potential epitopes are defined as short contiguous stretches of proteins, comparable in length to T-cell epitopes. This optimal coverage problem can be formulated in terms of a directed grap...
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ژورنال
عنوان ژورنال: Statistics in Medicine
سال: 2017
ISSN: 0277-6715
DOI: 10.1002/sim.7203